6-Amino-1-hexanol → HCID 21913650, compound

HRID 1245968Notes

Reaction equation

HRID 1245968 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[Cl:9][C:10]1[C:15]([N+:16]([O-:18])=[O:17])=[C:14](Cl)[C:13]([CH3:20])=[C:12]([CH3:21])[N:11]=1>>[Cl:9][C:10]1[C:15]([N+:16]([O-:18])=[O:17])=[C:14]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[C:13]([CH3:20])=[C:12]([CH3:21])[N:11]=1

Participants

3

Reactant 2

HCID 199606-Amino-1-hexanolHCID 121091232,4-Dichloro-5,6-dimethyl-3-nitropyridine

Product 1

HCID 21913650HCID 21913650, compoundYield 36.1%

Procedure

Using the general method of Example 89 Part A, 6-aminohexan-1-ol (15.91 g, 135.7 mmol) was reacted with 2,4-dichloro-5,6-dimethyl-3-nitropyridine (30 g, 136 mmol) to provide 14.79 g of 6-[(2-chloro-5,6-dimethyl-3-nitropyridin-4-yl)amino]hexan-1-ol as a yellow solid.

Sources & evidence

ORD record
ord-6f4e794a434f4d919f968c0b049f6e0e
Source dataset
uspto-grants-2006_10
Patent number
US07125890B2

Reaction notes

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