HRID1246048

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)Nc1cccc(CNC(=O)c2ccc(Cl)nc2)c1

HCID21914545

未命名化合物

2 次

结构：Cc1ccc(NC(=O)c2ccoc2)cc1B1OC(C)(C)C(C)(C)O1

HCID21914573

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccoc2)cc1-c1ccc(C(=O)NCc2cccc(NS(C)(=O)=O)c2)cn1

HCID21914567

未命名化合物

PROCEDURE

实验过程

6-[5-(Fur-3-ylcarbonylamino)-2-methyl-phenyl]-N-(3-methylsulphonylaminobenzyl)-nicotinamide was prepared from 6-chloro-N-(3-methylsulphonylaminobenzyl)nicotinamide (Intermediate 4) and N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-furamide (Intermediate 13) using General Method B. LCMS: retention time 2.93 min, MH+ 505. NMR: δH [2H6]-DMSO 9.99,(1H, s), 9.32,(1H, t), 9.15,(1H, d), 8.95,(1H, b), 8.38,(1H, s), 8.33,(1H, dd), 7.81,(2H, d), 7.75,(1H, d), 7.68,(1H, d), 7.33–7.30,(2H, m), 7.21,(1H, s), 7.11,(2H, m), 7.01,(1H, s), 4.51,(2H, d), 2.99,(3H, s), 2.32,(3H, s).