HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxindole → 3-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl) amide | HCID 86586196 | — |
| Reactant | 3-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester | HCID 86586197 | — |
| Product | 3-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide | HCID 67280972 | 21% |
Reaction Steps
Oxindole (66.5 mg, 0.5 mmol) was condensed with 5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide (prepared from 3-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester by method B then C) to give 39 mg (21%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125905B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-c00d5d48574747a691dcd504b40ffab8 |
| Source note | uspto-grants-2006_10 |