HRID1246140

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20761799

未命名化合物

结构：COc1ccc(NC(=O)c2cccc3c2CC(=O)N3)cc1Cl

HCID70160664

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(C(=O)Nc4ccc(OC)c(Cl)c4)c32)c1C

HCID67281648

未命名化合物

收率 93.1%

PROCEDURE

实验过程

2-Oxo-2,3-dihydro-1H-indole-4-carboxylic acid (3-chloro-4-methoxyphenyl)amide (1 g, 3.16 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (1 g, 3.58 mmol) to give 1.7 g (85%) of the title compound as a yellow-orange solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c37693c73195423ea0d3da0acedf89ed
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07125905B2
来源说明: uspto-grants-2006_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]3[CH2:15][C:16](=[O:22])[NH:17][C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH2:23]([N:25]([CH2:41][CH3:42])[CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]1[C:36]([CH3:37])=[C:35]([CH:38]=O)[NH:34][C:33]=1[CH3:40])=[O:31])[CH3:24]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]3[C:15](=[CH:38][C:35]4[NH:34][C:33]([CH3:40])=[C:32]([C:30](=[O:31])[NH:29][CH2:28][CH2:27][CH2:26][N:25]([CH2:41][CH3:42])[CH2:23][CH3:24])[C:36]=4[CH3:37])[C:16](=[O:22])[NH:17][C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]