P-Anisidine → HCID 178492247, compound

HRID 1246243Notes

Reaction equation

HRID 1246243 reaction equation
[F:1][C:2]1[C:3]([CH:8]=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1.S([O-])([O-])(=O)=O.[Na+].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:3](/[CH:8]=[N:18]/[C:15]2[CH:16]=[CH:17][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 7732P-AnisidineHCID 24436Sodium SulfateHCID 113440173-Fluoro-2-pyridinecarboxaldehyde

Product 1

HCID 178492247HCID 178492247, compoundYield 106.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Fluoro-2-formylpyridine (229 g) and paraanisidine (225 g) were dissolved in toluene (2.29 l). After adding anhydrous sodium sulfate (334 g), the mixture was stirred at room temperature for 1 hour. After filtering off the insoluble matters, the liquid reaction mixture was concentrated under reduced pressure to thereby give the title compound (449 g).

Workup

  1. filtrationAfter filtering off the insoluble matters
  2. customthe liquid reaction mixture
  3. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-6c46fdbefc144d30be01b8616a792deb
Source dataset
uspto-grants-2006_10
Patent number
US07126003B2

Reaction notes

Loading…