Methyl 4-(4-fluorophenyl)-4-oxobutanoate → Methyl 4-(4-fluorophenyl)butanoate

Participants

Reaction Steps

In a 500 ml round-bottomed flask, 0.095 mol of the compound obtained in Step B is dissolved in 250 ml of methanol. 1 g of 10% activated palladium-on-carbon is added and magnetic stirring is carried out under a hydrogen atmosphere for 12 hours. The palladiated carbon is then filtered off, and the methanol is evaporated off under reduced pressure. The oil obtained is purified by chromatography on silica gel.

Provenance & Evidence