4-(p-Fluorophenyl)butyric acid → 7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one

HRID 1246400Notes

Reaction equation

HRID 1246400 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1>O>[F:1][C:2]1[CH:3]=[C:4]2[C:5]([CH2:8][CH2:9][CH2:10][C:11]2=[O:13])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 685244-(p-Fluorophenyl)butyric acid

Product 1

HCID 103747647-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

0.055 mol of the compound obtained in Step D is introduced into a 500 ml round-bottomed flask together with 100 g of polyphosphoric acid. The reaction mixture is heated at 60° C. for 4 hours. The mixture is then cooled and poured into water; the precipitate formed is then dried and recrystallised.

Workup

  1. temperatureThe mixture is then cooled
  2. customthe precipitate formed
  3. customis then dried
  4. customrecrystallised

Sources & evidence

ORD record
ord-95d8fb647804467981711064421b089b
Source dataset
uspto-grants-2006_10
Patent number
US07126012B2

Reaction notes

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