2-Propanone, 1-(acetyloxy)-3-chloro- → (2-Aminothiazol-4-yl)methyl acetate hydrochloride

Participants

Reaction Steps

A mixture of 3-chloro-2-oxopropyl acetate (5 g) and thiourea (2.5 g) in ethanol (25 ml) was refluxed for 4 hours. The reaction mixture was cooled to ambient temperature and the resulting crystalline precipitate was collected by filtration and washed with ethanol (20 ml) to give (2-amino-1,3-thiazol-4-yl)methyl acetate hydrochloride (3.5 g) as white crystals.

Provenance & Evidence