Benzoyl isothiocyanate → N-{4-[2-(4-{[(benzoylamino)carbonothioyl]amino)phenyl)ethyl]-1,3-thiazol-2-yl}acetamide

Participants

Reaction Conditions

Reaction Steps

To an ice-cold solution of N-(4-(2-(4-aminophenyl)ethyl)-1,3-thiazol-2-yl)acetamide (300 mg) prepared in a similar manner according to Step 6 of Production Example 1 in acetone (5 ml) was added benzoyl isothiocyanate (187 mg) and the mixture was refluxed for 2 hours. The reaction mixture was cooled to 0° C. The precipitated crystals were filtered and washed with ice-cold acetone to give N-{4-[2-(4-{[(benzoylamino)carbonothioyl]amino}phenyl)ethyl]-1,3-thiazol-2-yl}acetamide (359 mg).

Provenance & Evidence