4-Cyanobenzaldehyde → [4-(Aminomethyl)phenyl]methanol

Participants

Role	Name	HCID	Charge
Reactant	4-Cyanobenzaldehyde	HCID 66042	—
Reactant	[3,5-Bis(benzyloxy)benzyl]amine hydrochloride	HCID 15505554	—
Product	[4-(Aminomethyl)phenyl]methanol	HCID 6496943	46%

Reaction Steps

This compound was prepared by reduction of 4-cyanobenzaldehyde according to the procedure described in preparation of 3,5-dibenzyloxybenzylamine. Yield was 46%: MP 102–123° C.; 1H NMR (Acetone-d6, 500 MHz) 7.27 (m, complex 4H), 4.58 (s, 2H), 3.72 (s, 2H), 3.69 (s, 1H) 2.77 (br, 1H), 2.45 (br, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07129225B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-75be941694c049b98881829bd5d73a42
Source note	uspto-grants-2006_10