HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate → 8-Benzyl-3,8-diazabicyclo[3.2.1]octan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate | HCID 66846370 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-Benzyl-3,8-diazabicyclo[3.2.1]octan-2-one | HCID 21904723 | — |
Reaction Steps
Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate (9.92 g, 35.9 mmol) and 5% platinum on activated carbon (11.25 g) were combined in methanol (100 mL) and shaken for 56 hours at ambient temperature under a hydrogen atmosphere (60 psi). The misture was filtered and the filtrate concentrated to provide the title compound. MS (DCI/NH3) m/z: 217 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129235B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b08555579183468dabae223e51a9e25f |
| Source note | uspto-grants-2006_10 |