HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tert-butyl-4-isocyanatobenzene → HCID 11292477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tert-butyl-4-isocyanatobenzene | HCID 2735695 | — |
| Reactant | 8-(3-Chloropyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane | HCID 21904769 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11292477 | HCID 11292477 | — |
Reaction Steps
8-(3-Chloro-2-pyridinyl)-3,8-diazabicyclo[3.2.1]octane (102 mg, 456 μmol) and 1-tert-butyl-4-isocyanatobenzene (80 mg, 456 μmol) were combined in dry dichloromethane (4.5 mL) and stirred overnight at room temperature. The mixture was concentrated and the residue was purified by chromatography on silica gel (7:3, hexanes:ethyl acetate) to provide the title compound. MS (ESI) m/z: 399 (M+H)+;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129235B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ffadd05394d24114bd4cb98e95d17321 |
| Source note | uspto-grants-2006_10 |