HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → 1-(3-Chloro-2-pyridinyl)-3-hydroxy-4-piperidinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 21904778 | HCID 21904778 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(3-Chloro-2-pyridinyl)-3-hydroxy-4-piperidinecarboxylic acid | HCID 21904787 | — |
Reaction Steps
Ethyl 1-(3-chloro-2-pyridinyl)-3-hydroxy-4-piperidinecarboxylate in water (55 mL) was treated with sodium methoxide (0.5 M, 8 mL, 4.0 mmol) at room temperature. After 2 hours, the mixture was concentrated under reduced pressure and the residue was purified by column chromatography to provide the title compound. MS (EI, M+H)+257.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129235B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ed69823d2ed14c069375cd4c6390daa9 |
| Source note | uspto-grants-2006_10 |