HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Benzyl-4-hydroxypiperidine-4-carbonitrile | HCID 80189 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate | HCID 12343427 | — |
Reaction Steps
1-Benzyl-4-hydroxy-4-piperidinecarbonitrile (30.0 g, 118 mmol) in methanol (590 mL) and concentrated HCl (590 mL) was heated at reflux for 18 hours. The product was obtained following chromatography (SiO2, ethyl acetate:hexane, 1:4). MS (EI, M+H)+250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129235B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-63c3eb8344b04961916492b7886eaae0 |
| Source note | uspto-grants-2006_10 |