HCID 4711777, compound → HCID 11305156, compound

HRID 1246729Notes

Reaction equation

[Cl:1][C:2]1([Cl:13])[CH2:4][C:3]1([C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)[CH3:5].CCC[C@@](O)([C@@H]1[C@@]2(OC)[C@@H:25]3[O:42]C4=C(OC(C)=O)C=CC5=C4[C@:26]43[CH2:27][CH2:28][N:29]([CH3:43])[CH:30](C5)[C@@:21]4(C=C2)C1)C.[ClH:47]>>[Cl:1][C:2]1([Cl:13])[CH2:4][C:3]1([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:25]([C:26]2[CH2:21][CH2:30][N:29]([C:43]3[C:6]([Cl:47])=[CH:7][CH:8]=[CH:9][N:12]=3)[CH2:28][CH:27]=2)=[O:42])=[CH:8][CH:7]=1)[CH3:5]

Participants

Reactant 2

HCID 4711777HCID 4711777, compound

HCID 90465825HCID 90465825, compound

Product 1

HCID 11305156HCID 11305156, compound

Procedure

The title compound was prepared using the procedure described in Example 49D using 4-(2,2-dichloro-1-methyl-cyclopropyl)-phenylamine instead of 4-tert-butylaniline. MS (DCI+) m/z 436 (M+H)+ (70%), m/z 252 (M−183)+ (100%); 1H NMR (300 MHz, DMSO-D6) δ ppm 1.61 (s, 3 H), 1.74 (d, J=7.5 Hz, 1 H), 2.14 (d, J=7.8 Hz, 1 H), 2.56 (m, 2 H), 3.45 (t, J=5.4 Hz, 2 H), 4.01 (q, J=3.0 Hz, 2 H), 6.77 (m, 1 H), 7.00 (dd, J=7.6, 4.6 Hz, 1 H), 7.27 (m, 2 H), 7.67 (m, 2 H), 7.83 (dd, J=7.6, 1.5 Hz, 1 H), 8.22 (dd, J=4.7, 1.7 Hz, 1 H), 9.75 (s, 1 H).

Sources & evidence

ORD record: ord-a271ed813fb84414a326c47a220a2b91
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129235B2

Reaction notes

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