HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Nitrite → 7-chloro-3-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyrimidine-2,4,5-triamine | HCID 58278607 | — |
| Product | 7-chloro-3-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine | HCID 21906137 | — |
Reaction Steps
A solution of 6-chloro-N4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-pyrimidine-2,4,5-triamine was treated with a cold aqueous solution of NaNO2, following the general procedure 2. HPLC RT was 3.597 min. 1HNMR (CDCl3): δ 8.22 (s, 1H), 7.12 (broad t, 1H), 4.61 (s, 2H), 4.56–4.55 (d, 2H), 3.80 (s, 3H), 3.00 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129244B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-1dd27972f6064733bc880686c38dda3b |
| Source note | uspto-grants-2006_10 |