HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → 6-chloro-N4-(4-methoxy-benzyl)-pyrimidine-2,4,5-triamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 2,5-Diamino-4,6-dichloropyrimidine | HCID 301039 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 6-chloro-N4-(4-methoxy-benzyl)-pyrimidine-2,4,5-triamine | HCID 86038947 | — |
Reaction Steps
A mixture of 4,6-dichloro-pyrimidine-2,5-diamine and 1-aminomethyl-4-methoxybenzene was refluxed in n-BuOH for 15 h, following the general procedure 1. HPLC RT was 4.675 min. 1HNMR (CDCl3) δ 7.29–7.27 (d, 2H), 6.91–6.89 (d, 2H), 5.62 (br. t, 1H) 4.67 (s, 2H), 4.56–4.54 (d, 2H), 3.84 (s, 3H), 2.74 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129244B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-64d1b0ee118d4f67af581da81ba5131c |
| Source note | uspto-grants-2006_10 |