HCID 21882854, compound → HCID 21906138, compound

HRID 1246746Notes

Reaction equation

HRID 1246746 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=2)[C:3]=1[NH2:23].[N:24]([O-])=O.[Na+]>>[Cl:1][C:2]1[C:3]2[N:23]=[N:24][N:9]([CH2:10][C:11]3[CH:12]=[C:13]([O:21][CH3:22])[C:14]([O:19][CH3:20])=[C:15]([O:17][CH3:18])[CH:16]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 2

HCID 21882854HCID 21882854, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21906138HCID 21906138, compound

Procedure

A solution of 6-chloro-N4-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,4,5-triamine was treated with a cold aqueous solution of NaNO2, following the general procedure 2. HPLC RT was 5.755 min. 1HNMR (CDCl3): δ 6.66 (s, 2H), 5.55 (s, 2H), 5.42 (s, 2H), 3.83 (s, 3H), 3.80 (s, 6H).

Sources & evidence

ORD record
ord-0c28f82ef66a4818b766f58a9821346b
Source dataset
uspto-grants-2006_10
Patent number
US07129244B2

Reaction notes

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