N-bromobutanimide → HCID 21906141, compound

HRID 1246748Notes

Reaction equation

HRID 1246748 reaction equation
[Cl:1][C:2]1[C:3]2[N:11]=[N:10][N:9]([CH2:12][C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.C1C(=O)N([Br:32])C(=O)C1>>[Cl:1][C:2]1[C:3]2[N:11]=[N:10][N:9]([CH2:12][C:13]3[CH:14]=[C:15]([O:23][CH3:24])[C:16]([O:21][CH3:22])=[C:17]([O:19][CH3:20])[C:18]=3[Br:32])[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 21906138HCID 21906138, compound

Product 1

HCID 21906141HCID 21906141, compound

Procedure

Bromination of 7-chloro-3-(3,4,5-trimethoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine) with NBS (1.5 equivalents) was done following the general procedure 3 to give the title compound: HPLC RT was 6.541 min. 1HNMR (CDCl3): δ 6.52 (s, 1H), 5.74(s, 2H), 5.46 (s, 2H), 3.93 (s, 3H), 3.89 (s, 3H), 3.76 (s, 3H).

Sources & evidence

ORD record
ord-0ef9e039ba9c4033916c10281fbcdde7
Source dataset
uspto-grants-2006_10
Patent number
US07129244B2

Reaction notes

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