Sodium Nitrite → HCID 21906142, compound

HRID 1246749Notes

Reaction equation

HRID 1246749 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([O:19][CH3:20])[CH:12]=2)[C:3]=1[NH2:21].[N:22]([O-])=O.[Na+]>>[Cl:1][C:2]1[C:3]2[N:21]=[N:22][N:9]([CH2:10][C:11]3[CH:12]=[C:13]([O:19][CH3:20])[CH:14]=[C:15]([O:17][CH3:18])[CH:16]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 2

HCID 23668193Sodium NitriteHCID 86038960HCID 86038960, compound

Product 1

HCID 21906142HCID 21906142, compound

Procedure

A solution of 6-chloro-N4-(3,5-dimethoxy-benzyl)-pyrimidine-2,4,5-triamine was treated with a cold aqueous solution of NaNO2, following the general procedure 2. HPLC RT was 6.185 min. 1HNMR (CDCl3): δ 6.54–6.53 (d, 2H), 6.41–6.40 (d, 1H), 5.58 (s, 2H), 5.54 (s, 2H), 3.78 (s, 6H).

Sources & evidence

ORD record
ord-fe0a1d02e3da498da36ebd4b779904ba
Source dataset
uspto-grants-2006_10
Patent number
US07129244B2

Reaction notes

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