2,2,2-Trifluoroethanol → HCID 21906044, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-hydroxy-1-piperidinecarboxylate (30.0 g), 2,2,2-trifluoroethanol (149 g) and triphenylphosphine (58.6 g) in tetrahydrofuran (450 ml) was slowly added diethyl azodicarboxylate (38.9 g) at 8° C. The mixture was stirred at room temperature for 2 hours, and at 60° C. for 8 hours. The reaction mixture was concentrated in vacuo to give the crude product of the title compound. The crude product was purified by chromatography on silica gel.

Provenance & Evidence