2-Fluorobenzoyl chloride → HCID 21905816, compound

Participants

Reaction Steps

2-Fluorobenzoyl chloride (93 μl, 0.78 mmol) was added to 6-chloro-N4-(4-chlorophenyl)-2-methylpyrimidine-4,5-diamine I-(7A-80)a (173 mg) and pyridine (1 ml) and stirred at room temperature for 7 h. The reaction was incomplete at this time so an additional 1.5 equivalents of 2-fluorobenzoyl chloride was added to the reaction mixture and continued stirring overnight at room temperature. The reaction was extracted from saturated NaHCO3 solution into ethyl acetate. The organic layers were combined, dried (Na2SO4), filtered, and concentrated to dryness to afford the desired crude product I-(7A-80)b (0.25 g): +ESI MS (M+1) 391.2.

Provenance & Evidence