1,4-Dioxane → HCID 131726010, compound

Participants

Reaction Steps

4-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-piperazine-1,3-dicarboxylic acid tert-butyl ester I-(8A-1)a was dissolved in 4 M HCl in dioxane (0.5 ml). After 30 minutes, the now heterogeneous reaction was concentrated under reduced pressure and then triturated from ether to afford title compound 8A-1 (38 mg, quantitative): +ESI MS (M+1) 497.2; 1H NMR (400 MHz, CD3OD) δ 8.43 (s, 1H), 7.58 (d, J=7.5 Hz, 1H), 7.51–7.30 (m, 7H), 4.35–4.15 (m, 2H), 4.06 (d, J=13.3 Hz, 1H), 3.73–3.47 (m, 5H), 3.40–3.30 (m, 1H), 1.23 (t, J=7.1 Hz, 3H).

Provenance & Evidence