Toluene → HCID 16117417, compound

Participants

Reaction Steps

A solution of compound 30 (20 mg, 0.05 mmole) and 1-acetyl piperazine (19.2 mg, 0.15 mmole) in toluene (1.0 ml) was stirred at 100° C. for five hours. Solvent was evaporated and the residue was purified on a 5-g silica gel cartridge eluting with EtOAc. The title compound 26 was obtained as a white solid. 11.2 mg, 45.8%. 1H-NMR (CDCl3, 300 MHz) δ1.18 (d, J=7.0 Hz, 6H), 2.15(s, 3H), 3.49–3.62 (m, 7H), 3.74 (m, 2H), 6.89 (d, J=8.0 Hz, 1H), 7.15–7.21 (m, 2H), 7.39–7.41 (m, 2H), 7.52 (s, 1H), 7.58 (d, J=8.0 Hz, 1H), 7.96 (s, 1H); MS (APCI) m/z 490(M+H)+.

Provenance & Evidence