1-Piperazinecarboxaldehyde → 4-(4-(4-(2-Methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-piperazine-1-carbaldehyde

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with 1-formylpiperazine. A yellow solid 99 was obtained (0.0159 g, 34%). 1H-NMR (CDCl3, 400 MHz) δ 3.62–3.65 (m, 2H), 3.68–3.72 (m, 2H), 3.75–3.78 (m, 2H), 3.83 (s, 3H), 3.86–3.89 (m, 2H), 6.95 (s, 1H), 7.02 (m, 3H), 7.08 (d, J=8.4 Hz, 1H), 7.46–7.52 (m, 3H), 7.86 (d, J=1.5 Hz, 1H), 8.16 (s, 1H), 8.30 (d, J=6.2 Hz, 1H); MS (APCI) m/z 474 (M+H)+.

Provenance & Evidence