4-Piperidinecarboxylic acid → 4'-(4-(2-Methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-carboxylic acid

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Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with isonipecotic acid. A yellow solid 106 was obtained (0.0225 g, 47%). 1H-NMR (CDCl3, 400 MHz) δ 1.90–1.99 (m, 2H), 2.09–2.16 (m, 2H), 2.68–2.77 (m, 1H), 3.43–3.50 (m, 2H), 3.83 (s, 3H), 4.14–4.20 (m, 2H), 6.95 (d, J=6.2 Hz, 1H), 6.99–7.05 (m, 3H), 7.06 (d, J=8.4 Hz, 1H), 7.45–7.52 (m, 3H), 7.84 (s, 1H), 8.20 (d, J=6.6 Hz, 1H); MS (APCI) m/z 489 (M+H)+.

Provenance & Evidence