4-Hydroxypyrrolidine → HCID 21906759, compound

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with N-acetylhomopiperazine. A yellow solid 112 was obtained (0.0246 g, 50%). 1H-NMR (CDCl3, 400 MHz) δ 2.02–2.10 (m, 2H), 2.08 (s, 3H), 3.55 (t, J=5.9 Hz, 1H), 3.59 (t, J=5.5 Hz, 1H), 3.79 (t, J=6.2 Hz, 1H), 3.83 (s, 3H), 3.84–3.92 (m, 3H), 4.05 (t, J=5.3 Hz, 1H), 4.15 (t, J=5.5 Hz, 1H), 6.86 (s, ⅓H), 6.89 (s, ⅔H), 6.92–7.08 (m, 4H), 7.45–7.53 (m, 3H), 7.84 (s, ⅓H), 7.85 (s, ⅔H), 8.26–8.30 (m, 1H); MS (APCI) m/z 502 (M+H)+.

Provenance & Evidence