4-Hydroxypyrrolidine → (3-(4-(4-(4-(2-Methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-piperazine-1-yl)-propyl)-dimethyl-amine

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with 1-(3-dimethylaminopropyl)piperazine. A yellow solid 113 was obtained (0.0414 g, 79%). 1H NMR (CDCl3, 400 MHz) δ 2.20–2.50 (br, 6H), 2.42–2.50 (m, 2H), 2.86 (s, 6H), 3.21–3.28 (m, 2H), 3.32–3.38 (br, 2H), 3.83 (s, 3H), 4.05–4.10 (br, 2H), 6.88 (s, 1H), 6.99–7.06 (m, 3H), 7.10 (d, J=8.2 Hz, 1H), 7.43–7.52 (m, 3H), 7.85 (s, 1H), 8.25 (d, J=5.5 Hz, 1H); MS (APCI) m/z 531 (M+H)+.

Provenance & Evidence