4-Piperidinecarboxamide → HCID 60108841, compound

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with isonipecotamide. A yellow solid 126 was obtained (0.024 g, 47%). 1H-NMR (CDCl3, 400 MHz) δ 1.90–1.99 (m, 2H), 2.08–2.14 (m, 2H), 2.58–2.65 (m, 1H), 3.38–3.45 (m, 2H), 4.28–4.34 (m, 6H), 5.55 (br s, 1H), 5.97 (br s, 1H), 6.93–6.98 (m, 3H), 7.05 (dd, J=2.0 Hz, 8.2 Hz, 1H), 7.09 (d, J=1.8 Hz, 1H), 7.12 (d, J=8.4 Hz, 1H), 7.53 (d, J=8.4 Hz, 1H), 7.82 (s, 1H), 8.21 (d, J=6.6 Hz, 1H); MS (APCI) m/z 516 (M+H)+.

Provenance & Evidence