4-Piperidinecarboxylic acid → HCID 10142564, compound

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with isonipecotic acid. A yellow solid 127 was obtained (0.014 g, 28%). 1H-NMR (CDCl3, 400 MHz) δ 1.89–1.98 (m, 2H), 2.08–2.15 (m, 2H), 2.68–2.76 (m, 1H), 3.40–3.48 (m, 2H), 4.13–4.20 (m, 2H), 4.28–4.34 (m, 4H), 6.91–6.98 (m, 3H), 7.04 (dd, J=1.9 Hz, 8.4 Hz, 1H), 7.09 (d, J=2.2 Hz, 1H), 7.12 (d, J=8.4 Hz, 1H), 7.52 (d, J=8.4 Hz, 1H), 7.82 (s, 1H), 8.20 (d, J=6.2 Hz, 1H); MS (APCI) m/z 517 (M+H)+.

Provenance & Evidence