4-Piperidineethanol → HCID 21906760, compound

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with 4-(2′-hydroxyethyl)piperidine. A yellow solid 129 was obtained (0.037 g, 73%). 1H NMR (CDCl3, 400 MHz) δ 1.35–1.44 (m, 2H), 1.55–1.60 (m, 2H), 1.84–1.93 (m, 1H), 1.97–2.03 (m, 2H), 3.22–3.30 (m, 2H), 3.74 (t, J=6.2 Hz, 2H), 4.28–4.34 (m, 4H), 4.36–4.42 (m, 2H), 6.91 (d, J=6.6 Hz, 1H), 6.93–6.96 (m, 2H), 7.05 (dd, J=2.2 Hz, 8.4 Hz, 1H), 7.09 (d, J=2.2 Hz, 1H), 7.12 (d, J=8.8 Hz, 1H), 7.51 (d, J=8.8 Hz, 1H), 7.81 (s, 1H), 8.24 (d, J=6.6 Hz, 1H); MS (APCI) m/z 517 (M+H)+.

Provenance & Evidence