L-Hydroxyproline → HCID 21906752, compound

Participants

Role	Name	HCID	Charge
Reactant	L-Hydroxyproline	HCID 5810	—
Reactant	4-Hydroxypyrrolidine	HCID 98210	—
Reactant	4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine	HCID 86585867	—
Product	HCID 21906752	HCID 21906752	—

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with trans-4-hydroxy-L-proline. A yellow solid 131 was obtained (0.017 g, 33%). 1H-NMR(CDCl3,400 MHz)62.42–2.51 (m, 1H),3.66–3.72(m, 1H), 3.85–3.91 (m, 1H), 4.00–4.06 (m, 1H), 4.28–4.34 (m, 4H), 4.64–4.69 (m, 1H), 4.89–4.95 (m, 1H), 6.81 (s, 1H), 6.92–6.96 (m, 2H), 7.03 (dd, J=1.8 Hz, 8.4 Hz, 1H), 7.06–7.10 (m, 2H), 7.50 (d, J=8.4 Hz, 1H), 7.79 (s, 1H), 7.92–7.96 (m, 1H); MS (APCI) m/z 519 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07129247B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-8810d9c846d84ac9bb0a7fa106a6b769
Source note	uspto-grants-2006_10