4-Hydroxypyrrolidine → HCID 21906805, compound

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with N-acetylhomopiperazine. A yellow solid 133 was obtained (0.021 g, 40%). 1H-NMR (CDCl3, 400 MHz) δ 2.01–2.10 (m, 2H), 2.08 (s, 3H), 3.52–3.60 (m, 2H), 3.76–3.91 (m, 4H), 4.01–4.06 (m, 1H), 4.11–4.16 (m, 1H), 4.28–4.34(m, 4H), 6.85 (s, ⅓H), 6.87 (s, ⅔H), 6.95 (d, J=8.4 Hz, 1H), 6.97 (d, J=6.6 Hz, 1H), 7.05 (dd, J=1.4 Hz, 8.4 Hz, 1H), 7.10 (d, J=2.2 Hz, 1H), 7.11–7.14 (m, 1H), 7.50–7.56 (m, 1H), 7.81 (s, ⅓H), 7.82 (s, ⅔H), 8.26–8.30 (m, 1H);MS (APCI) m/z 530 (M+H)+.

Provenance & Evidence