HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilic Acid → HCID 131726013, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilic Acid | HCID 227 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 21906962 | HCID 21906962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131726013 | HCID 131726013 | — |
Reaction Steps
A mixture of anthranilic acid (1.4 g) and 1-(4-aminophenyl)cyclobutane-carbonitrile (1 eq) and TEA (1.2 eq) in dichloromethane (80 ml) was stirred with EDCI (1.25 eq) and HOBt (1 eq) at RT overnight. The reaction was washed with sat. NaHCO3, H2O followed by brine, dried over Na2SO4 and evaporated. The residue was purified by column chromatography to give (2-aminophenyl)-N-[4-(cyanocyclobutyl)phenyl]-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129252B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-8a287090be5a45018a98dcd1707f9b18 |
| Source note | uspto-grants-2006_10 |