HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1246966Generated: October 30, 2026
Hydrochloric Acid → n-{4-[(Methoxymethyl)cyclobutyl]phenyl}{2-[(4-pyridylmethyl)amino]phenyl}-carboxamide
https://huagongshe.com/reaction/1246966
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | N-[2-(N-{4-[(methoxymethyl)-cyclopropyl]phenyl}carbamoyl)phenyl]-N-(4-pyridylmethyl)-acetamide | HCID 21906968 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | n-{4-[(Methoxymethyl)cyclobutyl]phenyl}{2-[(4-pyridylmethyl)amino]phenyl}-carboxamide | HCID 11429536 | — |
Reaction Steps
A mixture of N-[2-(N-{4-[(methoxymethyl)-cyclopropyl]phenyl}carbamoyl)-phenyl]-N-(4-pyridylmethyl)acetamide (100 mg) and 20% HCl (5 ml) in EtOH (15 ml) was stirred at 80° C. overnight. The solution was basified with NaHCO3 and evaporated with silica gel and purified by column chromatography to give the title compound. Mass: (M+1), 402.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07129252B2 |
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| Source dataset | uspto-grants-2006_10 |
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| ORD ID | ord-9e95ac56214e41ff8972b332a498ace7 |
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| Source note | uspto-grants-2006_10 |
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