HCID 21906966, compound → HCID 21906969, compound

HRID 1246967Notes

Reaction equation

HRID 1246967 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 21906966HCID 21906966, compound

Product 1

HCID 21906969HCID 21906969, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of [(4-nitrophenyl)cyclobutyl]methane-1-ol (500 mg) was mixed with Pd—C (10%, 80 mg) in EtOH (100 ml) and hydrogenated under H2 atmosphere for 1 hour. The reaction was filtered through Celite and evaporated to give [(4-aminophenyl)cyclobutyl]methane-1-ol.

Workup

  1. filtrationThe reaction was filtered through Celite
  2. customevaporated

Sources & evidence

ORD record
ord-d6117ebd0e204841afc471846e4ec56d
Source dataset
uspto-grants-2006_10
Patent number
US07129252B2

Reaction notes

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