反应详情

温度

130 °C

20.0 g (193.9 mmol) of 4-aminobutyric acid is mixed with 19 g of maleic acid anhydride, 290 ml of acetic acid, and it is heated for 4 hours in an oil bath at 130° C. It is azeotropically concentrated by evaporation with repeated addition of toluene, the residue is dissolved in dichloromethane and purified by chromatography on fine silica gel. 17.1 g (93.4 mmol, 48%) of the title compound is isolated as a crystalline solid.

1. concentrationIt is azeotropically concentrated by evaporation
2. additionaddition of toluene
3. dissolutionthe residue is dissolved in dichloromethane
4. custompurified by chromatography on fine silica gel