Triethylamine → 2-[1-(2-Carboxypyridin-4-yl)piperidin-4-ylmethylamino]-5-chloro-N-(5-chloropyridin-2-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	4-Chloropyridine-2-carboxylic acid	HCID 230890	—
Reactant	5-chloro-N-(5-chloropyridin-2-yl)-2-[(4-piperidinylmethyl)amino]benzamide	HCID 9886106	—
Solvent	Ethanol	HCID 702	—
Product	2-[1-(2-Carboxypyridin-4-yl)piperidin-4-ylmethylamino]-5-chloro-N-(5-chloropyridin-2-yl)benzamide	HCID 21906504	82%

Reaction Steps

Using a similar procedure to that described in Example 52, 5-chloro-N-(5-chloropyridin-2-yl)-2-(piperidin-4-ylmethyl)aminobenzamide (166 mg, 0.44 mmol), 4-chloropicolinic acid (103 mg, 0.66 mmol), triethylamine (89 mg, 0.88 mmol, and ethanol (3 mL) yielded 180 mg (82%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07129245B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-fc807513e3ec4f45b7aaf92c0fdbd256
Source note	uspto-grants-2006_10