2-Amino-5-chloropyridine → N-(5-chloropyridin-2-yl)-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylcarbonyl)aminobenzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-5-chloropyridine	HCID 66174	—
Reactant	2-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-4H-3,1-benzoxazin-4-one	HCID 21906637	—
Product	N-(5-chloropyridin-2-yl)-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylcarbonyl)aminobenzamide	HCID 21906181	—

Reaction Steps

Using a similar procedure to that described in example 51-D, 2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4H-3,1-benzoxazin-4-one (1.30 g, 4.51 mmol) and 2-amino-5-chloropyridine (573 mg, 4.51 mmol) yielded, after recrystallization from EtOAc, 880 mg (47%) of the titled compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07129245B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-53b5227c247c47c2aff9f11121405d28
Source note	uspto-grants-2006_10