HCID 21906228, compound → HCID 21906261, compound

HRID 1247135Notes

Reaction equation

HRID 1247135 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:30])[C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[NH:18][C:19]([CH:21]2[CH2:26][CH2:25][N:24]([CH:27]([CH3:29])[CH3:28])[CH2:23][CH2:22]2)=[O:20])=[N:7][CH:8]=1.FC(F)(F)C(O)=O.ClC1C=CC(NC(=O)C2C(F)=CC=CC=2NC(C2CCNCC2)=O)=NC=1>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:30])[C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[NH:18][C:19]([CH:21]2[CH2:22][CH2:23][N:24]([CH:27]([CH3:28])[CH3:29])[CH2:25][CH2:26]2)=[O:20])=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 21906228HCID 21906228, compoundHCID 21906517HCID 21906517, compound

Product 1

HCID 21906261HCID 21906261, compound

Procedure

Using methods substantially equivalent to those described in Example 231-E, N-(5-chloropyridin-2-yl)-6-fluoro-2-[(1-isopropylpiperidin-4-ylcarbonyl)amino]benzamide hydrochloride (0.345 g, 80%) was prepared from N-(5-chloropyridin-2-yl)-6-fluoro-2-[(4-piperidinylcarbonyl)amino]benzamide trifluoroacetate.

Sources & evidence

ORD record
ord-23041ad804d64699a19b97ce4fcc5229
Source dataset
uspto-grants-2006_10
Patent number
US07129245B2

Reaction notes

Loading…