2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-(1-hydroxyethyl)benzamide → N-(5-Chloropyridin-2-yl)-5-(1-hydroxyethyl)-2-[(4-piperidinylcarbonyl)amino]benzamide Trifluoroacetate

HRID 1247150Notes

Reaction equation

HRID 1247150 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].N1CCC(C(NC2C=CC=CC=2C(N)=O)=O)CC1.C(OC([N:33]1[CH2:38][CH2:37][CH:36]([C:39]([NH:41][C:42]2[CH:57]=[CH:56][C:55]([CH:58]([OH:60])[CH3:59])=[CH:54][C:43]=2[C:44]([NH:46][C:47]2[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][N:48]=2)=[O:45])=[O:40])[CH2:35][CH2:34]1)=O)(C)(C)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:53][C:50]1[CH:51]=[CH:52][C:47]([NH:46][C:44](=[O:45])[C:43]2[CH:54]=[C:55]([CH:58]([OH:60])[CH3:59])[CH:56]=[CH:57][C:42]=2[NH:41][C:39]([CH:36]2[CH2:37][CH2:38][NH:33][CH2:34][CH2:35]2)=[O:40])=[N:48][CH:49]=1

Participants

3

Reactant 2

HCID 219062392-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-(1-hydroxyethyl)benzamideHCID 700669162-[(4-Piperidinylcarbonyl)amino]benzamide trifluoroacetate

Product 1

HCID 21906445N-(5-Chloropyridin-2-yl)-5-(1-hydroxyethyl)-2-[(4-piperidinylcarbonyl)amino]benzamide Trifluoroacetate

Procedure

Using methods substantially equivalent to those described in Example 244-E, N-(5-chloropyridin-2-yl)-5-(1-hydroxyethyl)]-2-[(4-piperidinylcarbonyl)amino]benzamide trifluoroacetate (0.35 g, 86%) was prepared from 2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-(1-hydroxyethyl)benzamide.

Sources & evidence

ORD record
ord-9f75289a4c6e45f5a542731c7f9918b6
Source dataset
uspto-grants-2006_10
Patent number
US07129245B2

Reaction notes

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