Allyltributylstannane → 7-Allyl-2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol

Participants

Reaction Steps

The title compound was prepared in substantially the same manner as described in Example 24, Route c, step b, from 7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole, allyltributyltin and dichlorobis(tri-o'tolylphosphine)palladium, followed by demethylation according to Example 20, step e. The desired product was obtained as a light pink solid, m.p. 169–171° C.; MS m/e 284 (M−H)+.

Provenance & Evidence