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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1247236Generated: October 26, 2026

4-(Aminomethyl)benzonitrile → (R)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamide

https://huagongshe.com/reaction/1247236

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Aminomethyl)benzonitrileHCID 82608—
Reactant(R)-(-)-alpha-methoxyphenylacetic acidHCID 2724294—
Product(R)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamideHCID 69289951—

Reaction Steps

(R)-(+)-Methoxyphenylacetic acid was coupled with 4-aminomethyl benzonitrile (CAS No: 10406-25-4) according to general procedure C to give (R)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamide as an off-white solid. MS 281.1 ([M+H]+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07129238B2
Source datasetuspto-grants-2006_10
ORD IDord-7e34cf804a6047e4b11752793dcab563
Source noteuspto-grants-2006_10