4-(Aminomethyl)benzonitrile → HCID 21905551, compound

HRID 1247238Notes

Reaction equation

HRID 1247238 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)[C:4]([OH:6])=O.[NH2:20][CH2:21][C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=1>>[C:21]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][C:4](=[O:6])[CH:3]([O:2][CH3:1])[C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)=[CH:24][CH:23]=1)#[N:20]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21904922HCID 21904922, compound

Product 1

HCID 21905551HCID 21905551, compound

Procedure

(RS)-Methoxy-(4-phenoxy-phenyl)-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(4-phenoxy-phenyl)-acetamide. Colorless solid. MS 373.3 ([M+H]+)

Sources & evidence

ORD record
ord-29f78591626a47c0be10064de3031521
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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