4-(Aminomethyl)benzonitrile → HCID 21905585, compound

HRID 1247241Notes

Reaction equation

HRID 1247241 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:12][CH3:13])[C:9]([OH:11])=O.[NH2:14][CH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1>>[C:15]([C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH:21][C:9](=[O:11])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[O:12][CH3:13])=[CH:18][CH:17]=1)#[N:14]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288720103441-02-7

Product 1

HCID 21905585HCID 21905585, compound

Procedure

(RS)-(2-Fluoro-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-phenyl)-2-methoxy-acetamide. Colorless oil. MS 299.2 ([M+H]+)

Sources & evidence

ORD record
ord-688e5812ac8540b0b9a4918bcea11ee5
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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