4-(Aminomethyl)benzonitrile → HCID 21905342, compound

HRID 1247244Notes

Reaction equation

HRID 1247244 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=1)[C:4]([OH:6])=O.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[C:17]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH:23][C:4](=[O:6])[CH:3]([O:2][CH3:1])[C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)=[CH:20][CH:19]=1)#[N:16]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 19709581HCID 19709581, compound

Product 1

HCID 21905342HCID 21905342, compound

Procedure

(RS)-Methoxy-(3-nitro-phenyl)-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(3-nitro-phenyl)-acetamide. Light yellow gum.

Sources & evidence

ORD record
ord-777ef28339f24391a2a33e574cdbe5f8
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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