4-(Aminomethyl)benzonitrile → HCID 21905554, compound

HRID 1247245Notes

Reaction equation

HRID 1247245 reaction equation
[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([CH:7]([O:11][CH3:12])[C:8]([OH:10])=O)=[CH:3][CH:2]=1.[NH2:19][CH2:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=1>>[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:2]=[CH:3][C:4]([CH:7]([O:11][CH3:12])[C:8]([NH:26][CH2:25][C:24]2[CH:27]=[CH:28][C:21]([C:20]#[N:19])=[CH:22][CH:23]=2)=[O:10])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288162HCID 69288162, compound

Product 1

HCID 21905554HCID 21905554, compound

Procedure

(RS)-Biphenyl-4-yl-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-biphenyl-4-yl-N-(4-cyano-benzyl)-2-methoxy-acetamide. Light yellow solid.

Sources & evidence

ORD record
ord-e0751480f11f435c8f4565c3f31b69a6
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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