4-(Aminomethyl)benzonitrile → HCID 21905013, compound

HRID 1247246Notes

Reaction equation

HRID 1247246 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([O:14][CH3:15])[C:11]([OH:13])=O)=[CH:9][C:4]=2[O:3][CH2:2]1.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([O:14][CH3:15])[C:11]([NH:23][CH2:22][C:21]3[CH:24]=[CH:25][C:18]([C:17]#[N:16])=[CH:19][CH:20]=3)=[O:13])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 67372401HCID 67372401, compound

Product 1

HCID 21905013HCID 21905013, compound

Procedure

(RS)-Benzo[1,3]dioxol-5-yl-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-benzo[1,3]dioxol-5-yl-N-(4-cyano-benzyl)-2-methoxy-acetamide. Light yellow solid.

Sources & evidence

ORD record
ord-ab5d13a482a64b9e8c4fe39116369ac5
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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