4-(Aminomethyl)benzonitrile → HCID 21904868, compound

HRID 1247247Notes

Reaction equation

HRID 1247247 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([O:17][CH:18]2[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]2)[C:7]([F:16])=[C:8]([CH:10]([O:14][CH3:15])[C:11]([OH:13])=O)[CH:9]=1)[CH3:2].[NH2:25][CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=1>>[C:26]([C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH:32][C:11](=[O:13])[CH:10]([C:8]2[CH:9]=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=[C:6]([O:17][CH:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)[C:7]=2[F:16])[O:14][CH3:15])=[CH:29][CH:28]=1)#[N:25]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288918HCID 69288918, compound

Product 1

HCID 21904868HCID 21904868, compound

Procedure

(RS)-[5-Ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-2-methoxy-acetamide. Colorless foam. MS 456.5 ([M+H]+)

Sources & evidence

ORD record
ord-957d73999daa49b3af64fceb1dc0e8b5
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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