4-(Aminomethyl)benzonitrile → HCID 21905311, compound

HRID 1247252Notes

Reaction equation

HRID 1247252 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]([O:14][CH3:15])[C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[C:17]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH:23][C:11](=[O:13])[CH:10]([C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=2)[O:14][CH3:15])=[CH:20][CH:19]=1)#[N:16]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288839HCID 69288839, compound

Product 1

HCID 21905311HCID 21905311, compound

Procedure

(RS)-(3-Hydroxy-4-methoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(3-hydroxy-4-methoxy-phenyl)-2-methoxy-acetamide. White foam.

Sources & evidence

ORD record
ord-fa69fe8952fe4f51ac940a40a8cd6641
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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